This follows a draw conducted by the Football Association of Malawi (FAM) at its offices at Mpira Village in Blantyre on Thursday.
Bullets, who reached this stage after beating Dwangwa United 4-1, will battle for quarter-final ticket against the winner between Rumphi Medicals and Karonga United at MDC Ground on October 25.
The winner between Umodzi FC and Makawa Young Navy FC will play host to the winner Swallows FC and Madzi FC either at Kalulu Stadium or Balaka Stadium on October 26.
Last year's losing finalists, Kamuzu Barracks, who booked the ticket for this stage after beating Blantyre United, will play away to winners between Chikwawa United and Mangochi Challengers either at Kalulu Stadium or Balaka Stadium on October 25.
The winner between Dedza Soccer Saints and Dzaleka FC will play host to winner Nkhanga FC and Nsuwadzi FC either at Dedza Stadium or Dowa Ground on October 26.
Likewise, Azam Tigers has ducked teams from the Super League side as they have been drawn against teams from the lower league sides. They will host the winner between Holy Cross Ambassadors and Mlatho Mponela at MDC Ground on October 26.
Moyale FC will face the winner between Baka FC and Katowo FC at Mzuzu Stadium on October 26. However, the draw set two all-Super League encounters.
Mafco FC, who beat Silver Strikers, will face off with Masters Security at Chitowe Stadium. Master Security equally reached this stage after claiming a 3-1 away win over Red Lions.
Blue Eagles, who reached this stage after hammering Chitipa United 4-1, will host Mzuni FC, who beat Wizards FC 3-1. This match will be played at Nankhaka Stadium on October 25.
Commercial Director at Fam, Limbani Cliff Matola expressed satisfaction with progress of the tournament.
"We are looking forward to seeing more exciting matches. While others claim to have been paired with small teams, we feel there is no small team in this tournament. Teams that reached this stage demonstrated great character in them and deserved to be in the last 16," said Matola.