The league leaders pocketed three points, thanks to Jaffalie Chande's 27th minute goal.
Wanderers now have 50 points from 21 games while Wizards are on position 11 with 22 points from 22 games.
Second placed and third placed Silver Strikers and Nyasa Bullets have 42 and 41 points from 20 games each, respectively.
Bullets host Moyale FC at MDC Ground in Chilomoni, Blantyre whereas Silver face off with Azam Tigers at Silver Stadium on Monday.
Back to Balaka Stadium, both teams pressed for early goals, but lady lucky only smiled at the home side through Chande.
Chande connected home after receiving a through ball from enterprising midfielder Joseph Kamwendo.
Wizards, despite having better ball possession, failed to convert a number scoring opportunities they created in both halves.
Forward Esau Kanyenda and defender Harry Nyirenda were separately stretched off the pitch due to injuries and were replaced by Khumbo Ng'ambi and Foster Namwera, respectively.
After the final whistle, Wanderers Team Manager Steve Madeira praised his charges for maintaing the perfect run in the top flight league.
"We struggled a lot, but the boys managed to score a goal that has enabled us to collect much needed three points to stretch the lead on the log table.
"We now have a week to prepare for our next games against Chitipa United and Moyale. We are eyeing six points," Madeira said.
While caretaker coach for Wizards Simeon Kapuza conceded defeat, but quickly said they will work hard to survive relegation.
Elsewhere, Chitipa United and Masters Security pocketed a point each after settling for 1-all draw at Mzuzu Stadium.
The hosts scored through Alick Phiri while Arion Chefu netted for Masters Security.
Blantyre United suffered a 4-1 home defeat to Moyale FC at MDC Ground. While at Chitowe Stadium, Hassan Chapola's goal enabled Mafco FC to claim a 1-0 home win over their brothers in arms, Red Lions.
Kamuzu Barracks thrashed Blue Eagles 3-1 at Civo Stadium. KB netted through Mude Jeffrey (penalty), Sammy Chiponda and Kelvin Hanganda with Mphatso Philimon grabbing Blue Eagles' consolation goal.