The results some teams will register this week will either enable them to move up or climb down on the 16-member log table.
For instance, four teams—Tigers FC, Karonga United, Masters Security and Dwangwa United have 23 points each from 18 games save for Karonga United who have played 20 games.
Moyale FC and Kamuzu Barracks have 21 points from 18 games each while Mafco and Mzuni are tied on 15 points with Mafco having a superior goal difference and a game in hand.
The match of the week involves league leaders Nyasa Big Bullets and second placed Be Forward Wanderers at Kamuzu Stadium on Saturday.
The two sides pocketed a point each in the first round after settling for a goalless draw. Bullets are eyeing nothing but a win to stretch their lead while Wanderers hope to redeem all the three points in order to narrow the gap with Bullets.
Bullets top the log table with 45 points while Wanderers, who also want to ensure their title defence credentials, have 38 points from 19 games apiece.
Both sides seem to be in rampant form having done well in their four second round matches.
Third placed Silver Strikers will play away to Mafco FC at Chitowe Stadium. Silver have 36 points from 18 games, two points behind Wanderers while Mafco look forward to jumping out of the relegation as they are third from the bottom.
Civil Sporting, who are winless in four second round matches, will play away to Moyale and Mzuni FC on Saturday and Sunday, respectively. Civil climbed down to fifth position after losing 0-1 to Wanderers last weekend and hope to make two wins out of two in the northern region.
They have 26 points from 18 games, two points behind Blue Eagles, who will equally play away to Masters Security at Dedza Stadium on Sunday. Masters are on ninth position having played 18 games, just like Blue Eagles.
However, it will be a daunting task considering that Moyale and Mzuni equally aim for maximum points to move up or reduce the gap with teams above them.
Seventh-placed Tigers FC will play away to Dwangwa United at Chitowe Stadium on Sunday. Tigers want to make up for the 1-2 home defeat to Karonga United while the 2-1 home win over Kamuzu Barracks last weekend, may give Dwangwa United, who are perched on tenth position, may drive up their resilience.
Moyale, who have played 18 games, are on twelfth position while Mzuni are second from the bottom and have played 19 games.
Kamuzu Barracks (KB) and TN Stars will face off at Kasungu Stadium. KB are on thirteenth position while TN Stars are on sixth position with 24 points from 18 games.
Red Lions will host Nchalo United at Mangochi Stadium. Red Lions are on eleventh position with 22 points from 19 games while Nchalo are anchoring the log table with 11 points from 18 games.