Accepting the mantle, Chakwera called for equality in the global distribution and production of COVID-19 vaccines.
He said Africans have a moral duty to ratify the African free trade agreement.
He emphasized that Africa must insist on getting at least one seat on the Security Council of the United Nations.
Handing over the position, Nyusi said his country will support Malawi throughout its Chairmanship of SADC as Malawi helped his country during its one year stay at the helm of the regional grouping.
He said the impact of COVID-19 pandemic is still being felt in the SADC region as evidenced by the high number of deaths being registered on a daily basis.
Nyusi, assumed the Chairpersonship of SADC from former Tanzanian President late John Pombe Magufuli on August 17, 2020.